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MercurysBall2 ago

PROCEEDINGS OF THE ROUND TABLE ON Lysergic Acid Diethylamide and Mescaline in Experimental Psychiatry - American Psychiatric Association, 1955 - https://www.samorini.it/doc1/alt_aut/ad/cholden-lysergic-acid-diethylamide-and-mescaline-in-experimental-psychiatry.pdf

Attendees inclded: Harold A. Abramson, M.D., Mt. Sinai Hospital , New York, New York, Eugene S. Boyd, Rochester State Hospital; A. Cerletti, Sandoz Basel Switzerland; Edward Evarts, National Institute of Mental Health Maryland; Aldous Huxly;

...Mental phenom ena, produced by mescaline, were especially the object of intensive research in England by Osmond and Smythies . .. adrenochrome, an adrenaline metabolite, attracted their interest... They reported the results of a number of experiments with adrenochrome, .. They observed marked psychological changes... In discussing their observations, the authors state that "adrenochrome is the first substance thought to occur in the body which has shown to be a hallucinogen."

..We hypothesized the involvement of the adrenalin cycle in the production of psychoses. .. Of such adrenalin met abolite s, two have been described: adrenochrome, which ha s been isolated, and adrenoxine, which has not yet been isolated. P. Heirman ,9,10,11 however , obtained adrenoxine by carrying enzymatic adrenalin oxidation beyond the adrenochrome level. Pharmacologic and physiologic effects of adrenoxine, according to his description , seem to be similar to th ose obtained by LSD administration.