[1958] Adrenochrome monosemicarbazone (adrenoxyl) - An interim evaluation of its effect in reducing blood loss by J.. Shegog Ruddell,

After using adrenoxyl (adrenochrome monosemicarbazone) in the premedication for certain surgical operations for over a year a clinical impression was formed that when adrenoxyl had been given there was considerably less bleeding than if it had not been used, the same anasthetic technique notwithstanding.

Adrenoxyl (adrenochrome monosemicarbazone) is a stabilised form of adrenochrome... Adrenochrome was first isolated by Green and Richter1 by oxidising adrenaline, and was shown to produce capillary hamostasis as effectively as adrenaline2 although its instability rendered it unsuitable for use in human therapeutics.

This difficulty was overcome by the preparation of a stabilised form of adrenochrome, the monosemicarbazone of adrenochrome

(adrenoxyl). This, like adrenochrome, produces capillary haemostasis without exerting any of the actions characteristic of adrenaline on

cardiac frequency, blood pressure or respiration. Moreover adrenoxyl has no effect on blood coagulation.

[1997] Formation of adrenochrome from epinephrine by myeloperoxidase via a free radical: Its biological significance

The present study suggests a further biological role of myeloperoxidase in the promotion of healing. At a site of trauma or phlogosis, where there is an accumulation of body fluids, which normally lie within the range from neutral to slightly or moderately alkaline, or where the environment becomes neutral to slightly alkaline, the myeloperoxidase released from neutrophils 19,20) functions as part of a system generating adrenochrome. This, in turn, may participate in wound healing by promoting the formation of a blood clot and/or scab by radical polymerization, forming a melanin-like substance 1), and resulting in the acceleration of hemostasis.

Myeloperoxidase https://en.wikipedia.org/wiki/Myeloperoxidase

Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17.[5] MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity.[5][6] It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation.[7] Neutrophil myeloperoxidase has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus. The green color contributed to its outdated name verdoperoxidase.

External IDs- OMIM: 606989 MGI: 97137 HomoloGene: 55450 GeneCards: MPO GeneCards is a database of human genes that provides genomic, proteomic, transcriptomic, genetic and functional information on all known and predicted human genes. It is being developed and maintained by the Crown Human Genome Center at the Weizmann Institute of Science.

[2015] The effect of electromagnetic radiation emitted by display screens on cell oxygen metabolism – in vitro studies - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697066/

A CARY 100 BIO spectrophotometer (VARIAN) was used for the measurement of superoxide dismutase activity at 480 nm wavelength.

Cary spectrophotometers are made by Agilent Technologies https://en.wikipedia.org/wiki/Agilent_Technologies

Agilent Technologies, Inc. is a public research, development and manufacturing company established in 1999 as a spin-off from Hewlett-Packard.. Based on 2003 information, Agilent maintained four locations in the San Francisco Bay area: San Jose, Santa Clara, Santa Rosa and Rohnert Park.[3] Santa Clara is an R&D site,[3] containing the Agilent Research Laboratories group... Based on 2006 information, Agilent maintained seven sites in China: an office in Beijing, and branches in Shanghai, Chengdu, Guangzhou, Shenyang, Shenzhen and Xi'an.[4] Agilent also has several manufacturing facilities across Europe, most notably in Waldbronn Germany, Oxfordshire U.K. and Glostrup Denmark.

Agilent serves analytical laboratories and the clinical and routine diagnostics markets with a full suite of technology platforms. These include: automation, bioreagents, FISH probes, gas and liquid chromatography, immunohistochemistry, informatics, mass spectrometry, microarrays, spectroscopy, target enrichment, and vacuum technologies.

In August 2005, Agilent announced the sale of its semiconductor business, which produced chips for a wide range of consumer and industrial uses, to Kohlberg Kravis Roberts and Silver Lake Partners for $2.66 billion. .. Also in August 2005, Agilent sold its 47% stake in the light-emitting diode manufacturer Lumileds to Philips for $1 billion.[1] Lumileds originally started as Hewlett-Packard's optoelectronics division.

As of 2017, Agilent Technologies is mainly held by institutional investors: T. Rowe Price, BlackRock, Fidelity Investments, The Vanguard Group, State Street Corporation, and others.

Imperial partners with Agilent to boost molecular research and innovation - https://www.imperial.ac.uk/news/185073/imperial-partners-with-agilent-boost-molecular/

A deal has been signed for a suite of equipment that will promote research collaboration at the new Molecular Sciences Research Hub in White City. Agilent Technologies designs and creates instruments, software, services, and solutions for scientific analysis. As part of the deal, they will equip a new Agilent Measurement Suite in the Molecular Sciences Research Hub as well as provide other instrumentation throughout the building...

Professor Tony Cass, from the Department of Chemistry and Institute of Biomedical Engineering at Imperial has been appointed Director of the Agilent Measurement Suite. Professor Cass will oversee the collaboration with an objective to develop and facilitate translation of research, tools and technology from academia to industry

Prof Tony Cass, London Centre for Nanotechnology https://www.london-nano.com/our-people/our-people-bios/tony-cass

[2016]Neural correlates of the LSD experience revealed by multimodal neuroimaging - https://www.pnas.org/content/113/17/4853

reference: 22.↵Schwarz BE, Sem-Jacobsen CW, Petersen MC (1956) Effects of mescaline, LSD-25, and adrenochrome on depth electrograms in man. AMA Arch Neurol Psychiatry 75(6):579–587

This study was approved by the National Research Ethics Service committee London-West London and was conducted in accordance with the revised declaration of Helsinki (2000), the International Committee on Harmonization Good Clinical Practice guidelines, and National Health Service Research Governance Framework. Imperial College London sponsored the research, which was conducted under a Home Office license for research with schedule 1 drugs. For more methods see SI Appendix, Methods.