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MercurysBall2 ago

German wiki: Adrenochrome https://de.wikipedia.org/wiki/Adrenochrom

Adrenochrome is a metabolic product of adrenaline and is involved in the formation of the skin pigment . It was further investigated in 1952 as part of clinical studies to understand schizophrenia and how to combat it. It is closely related to adrenolutin, which has similar properties. It belongs to the chemical group of aminochromes.

[Actually it's been studies since the 1930s - see below]

In the early 1950s, all sorts of means to combat mental illnesses were researched. A. Hoffer and H. Osmond presented u. a. hypothesized that the body's own adrenochrome, which was discovered in the 1940s, fueled the “imagination” of schizophrenic personalities and thus made a decisive contribution to the clinical picture. [4] They referred to this hypothesis as the adrenochrome hypothesis, which should expand the current and recognized dopamine hypothesis and lead to new treatment methods.

The hallucinogenic effects of adrenochrome were also discovered in the course of their studies on the intervention in the body's adrenochrome household to treat schizophrenic personalities. This effect seemed very similar to that of LSD and mescaline, if not as potent. Hoffer and Osmond then hypothesized that LSD and mescaline boost the body's production of adrenochrome and are therefore only responsible for its hallucinogenic effects. They described their studies on hallucinogenic effects in 1967 in their joint textbook "The Hallucinogens".

MercurysBall2 ago

Humphry Osmond https://en.wikipedia.org/wiki/Humphry_Osmond

Humphry Fortescue Osmond (1 July 1917 – 6 February 2004) was an English psychiatrist who expatriated to Canada, then moved to work in the United States. He is known for inventing the word psychedelic and for his research into interesting and useful applications for psychedelic drugs. Osmond also explored aspects of the psychology of social environments, in particular how they influenced welfare or recovery in mental institutions.

After the war, Osmond joined the psychiatric unit at St George's Hospital, London where he rose to become senior registrar. His time at the hospital was to prove pivotal in three respects, firstly it was where he met his wife Amy "Jane" Roffey who was working there as a nurse, secondly he met Dr John Smythies who was to become one of his major collaborators, and thirdly he first encountered the drugs that would become associated with his name (and his with theirs): LSD and mescaline.

At Weyburn, Osmond recruited a group of research psychologists to turn the hospital into a design-research laboratory. There, he conducted a wide variety of patient studies and observations using hallucinogenic drugs, collaborating with Abram Hoffer and others. In 1952, Osmond related the similarity of mescaline to adrenaline molecules, in a theory which implied that schizophrenia might be a form of self-intoxication caused by one's own body. He collected the biographies of recovered schizophrenics, and he held that psychiatrists can only understand the schizophrenic by understanding the rational way the mind makes sense of distorted perceptions. He pursued this idea with passion, exploring all avenues to gain insight into the shattered perceptions of schizophrenia, holding that the illness arises primarily from distortions of perception. Yet during the same period, Osmond became aware of the potential of psychedelics to foster mind-expanding and mystical experiences.

In 1953, English-born Aldous Huxley was long-since a renowned poet and playwright who, in his twenties, had gone on to achieve success and acclaim as a novelist and widely published essayist. He had lived in the U.S. for well over a decade and gained some experience screenwriting for Hollywood films. Huxley had initiated a correspondence with Osmond. In one letter, Huxley lamented that contemporary education seemed typically to have the unintended consequence of constricting the minds of the educated—close the minds of students, that is, to inspiration and to many things other than material success and consumerism. In their exchange of letters, Huxley asked Osmond if he would be kind enough to supply a dose of mescaline.

Osmond's interests included the application of Jung's Typology of personality to group dynamics. He and Richard Smoke developed refinements of Jung's typology and applied them to analysis of the presidents and other world figures. Osmond also studied parapsychology.

Later, Osmond became director of the Bureau of Research in Neurology and Psychiatry at the New Jersey Neuro Psychiatric Institute (NJNPI) in Princeton, where he collaborated with Bernard Aaronson in hypnosis experiments. Still later, he became a professor of psychology at the University of Alabama in Birmingham. Osmond co-wrote eleven books and was widely published throughout his career.