If Freud and the McCanns are both innocent, I think Freud would have mentioned to the McCanns that the Podestas were staying at the residence during the time of the disappearance if that was in fact the case. If for no other reason just to name-drop during their dinner and conversations. And then when the e-fits came out the McCanns would have been screaming about it if they are totally innocent.

That probably means that the Podestas weren't there and if they were, then their presence was used as an opportunity to commit the crime and pin it on the Podestas and the McCanns would almost certainly be in on it if that scenario pans out.