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septimasexta ago

"Moderna was founded in 2010 and the name was originally written "ModeRNA".[3] It was based on basic science work by Derrick Rossi at Harvard, whose lab developed a method for modifying mRNA, transfecting into human cells, and dedifferentiating them into stem cells, and then causing them to differentiate into desired cell types.[4] Rossi approached fellow Harvard faculty member Tim Springer who had started a company before, about starting a company and Kenneth R. Chien; they brought in Bob Langer and then all of them met with Noubar Afeyan, the CEO of Flagship Ventures.[4][5] After some further validating experiments, the company was founded.[4] Stéphane Bancel, left his job as CEO of bioMérieux to become CEO in 2011.[4] It operated in stealth mode until December 2012, with a vague website and all employees working under strict confidentiality agreements;[5][6] People thought Moderna was a stem cell company until it emerged from stealth mode in 2012, by which time it had raised $40 million from Flagship Ventures' VentureLabs unit and other private investors.[2][4]

In March 2013, Moderna and AstraZeneca signed a five-year exclusive option agreement to discover, develop and commercialize mRNA therapeutics for the treatment of serious cardiovascular, metabolic and renal diseases as well as selected targets in oncology.[7][8] The agreement included a $240 million upfront payment to Moderna, a payment that is "one of the largest ever initial payments in a pharmaceutical industry licensing deal that does not involve a drug already being tested in clinical trials."[7]

In October 2013, the Defense Advanced Research Projects Agency (DARPA) awarded Moderna a grant worth up to $24.6 million to research and develop its mRNA drug technology to fight infectious diseases and biological weapons."

https://en.wikipedia.org/wiki/Moderna

"RNA vaccines: a novel technology to prevent and treat disease"

"Have you heard about RNA vaccines? This technology recently made the news when the Bill & Melinda Gates Foundation invested $53 million in the German company, CureVac, which specializes in the development of these vaccines [1]. In this article, we will discuss how RNA vaccines work, their main advantages compared to traditional vaccines, and their applications in diseases such as influenza and cancer."

http://sitn.hms.harvard.edu/flash/2015/rna-vaccines-a-novel-technology-to-prevent-and-treat-disease/

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