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MercurysBall2 ago

This is fascinating : amyloidosis and kuru.

Kuru: Genes, Cannibals and Neuropathology https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120877/

Kuru was the first human transmissible spongiform encephalopathy (TSE) or prion disease identified, occurring in the Fore linguistic group of Papua New Guinea. Kuru was a uniformly fatal cerebellar ataxic syndrome, usually followed by choreiform and athetoid movements. Kuru imposed a strong balancing selection on the Fore population, with individuals homozygous for the 129 Met allele of the gene (PRNP) encoding for prion protein (PrP) being the most susceptible. The decline in the incidence of kuru in the Fore has been attributed to the exhaustion of the susceptible genotype and ultimately by discontinuation of exposure via cannibalism. Neuropathologically, kuru-affected brains were characterized by widespread degeneration of neurons, astroglial and microglial proliferation, and the presence of amyloid plaques.

volunteerwork2020 ago

Pittsburgh's heroin and fentanyl epidemics are really bad. They use drug addicts in satanic cults as slaves since it is easier to control them by giving them the drug their bodies yearn for. They often do a lot of dirty work.

volunteerwork2020 ago

Also most of the heroin and fentanyl here comes from China or Mexico.