Process for preparing adrenochrome (QRV)

submitted ago by 3731626?

I found this on G..gle Patents, just to share..

https://patents.google.com/patent/US4501923A/en

Not sure what to do with it, lots of scientific stuff, but it seems the patent is expired.

Here's another text:

Process for preparing adrenochrome

Patent number: 4501923

Abstract: A process is described for preparing adrenochrome comprising oxidizing adrenaline or a salt thereof with a persulfate in an aqueous medium at a pH in the range 4 to 8 in the presence of one or more water-soluble salts of bismuth.

Type: Grant

Filed: September 13, 1982

Date of Patent: February 26, 1985

Assignee: Minnesota Mining and Manufacturing Company

Inventor: Deryck F. Boot

https://patents.justia.com/inventor/deryck-f-boot

23213240? ago

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23114550? ago

IPOT did an hour long special on this last week with more to follow.

23113387? ago

Adrenochrome monoaminoguanidine and adrenochrome monosemicarbazone are useful as hemostatics and these hydrazine derivatives serve both for stabilization of adrenochrome and the preparation of useful medicines.

They're basically just using this method to turn adrenaline into adrenochrome:

Generally, a uniform aqueous solution of adrenaline is first prepared by adding an acid such as hydrochloric acid to an aqueous dispersion of adrenaline, or by directly dissolving a salt of adrenaline in water.

If you have any questions about it I get the science here, ask away :)

TLDR: it's a method for turning adrenaline into adrenochrome in order to make drugs like hemostatics, which stop bleeding.

23113867? ago

But would synthesized adrenochrome have the same psychoactive properties that the 'natural' stuff is ment to have?

23113922? ago

It would be the same stuff. It's the same chemical. It would probably be way more effective, because it would be a lot easier to take a higher dose. Adrenaline is cheap and this process sounds simple enough.

23113971? ago

Could it be possibe that it's only 'activated' by a certain proccess in the human body? Like the way eating a cannabis bud would not do much but activating it first would get me very stoned? I just find it hard to imagine anyone would harvest this stuff from a human if they could just buy better quality online without breaking any laws.

23114011? ago

TBH, if you wanted to experience adrenochrome effects, the best way to do it would be to either do something that triggered adrenaline, or injure yourself. The rush you'd get from it is going to be the same experience you get when you've had some sort of injury or been attacked, minus the damage.

It causes thought disorder, derealization, and euphoria. If you've ever had a bad accident, you'll be familiar with the way your brain protects you from the severity of the injury - you get light headed, dissociate a bit, sometimes babble about random stuff, and sometimes feel weirdly euphoric.

23113985? ago

Not really. I genuinely don't get why anyone would do this, given that you could make a purer, higher dose pretty simply in a lab. The process you linked won't be the only one given that it is already used in other drugs (like the ones used to stop bleeding - that's one of the reasons adrenaline is produced when you hurt yourself, it can be turned into adrenochrome and other substances that help your body repair damage).

23113395? ago

Thanks for that, how do they get the Adrenochrome??

23113499? ago

In case you also want to know how adrenaline (aka epinephrine) is synthesized in the lab:

https://msfontainepinephrineproject.weebly.com/synthesis.html

Epinephrine may be artifically produced by the reaction of catechol and chloroacetyl chloride. This resulting compound is then reacted with methylamine, which is then reduced to a hydroxylic compound. Epinephrine may then be separated using tartaric acid.

TLDR: they take two compounds produced by other chemical processes, react them together, react the new compound with another reagent, and then they use another one to separate it (probably by turning it into a precipitate that can then be filtered out, not exactly sure but that's an educated guess).

23113453? ago

They get adrenaline, and oxidise it. They do this by adding some bismuth salts (the catalyst) and a persulfate reagent.

The oxidation reaction of adrenaline with the persulfate is conducted in an aqueous medium at pH 4 to 8 in the presence of one or more water-soluble bismuth salts. Generally, a uniform aqueous solution of adrenaline is first prepared by adding an acid such as hydrochloric acid to an aqueous dispersion of adrenaline, or by directly dissolving a salt of adrenaline in water. The aqueous solution is then added to a separately prepared aqueous medium containing the persulfate, the bismuth catalyst and the buffer.

So, they take adrenaline and use the process (which is what they are trying to patent) to make adrenochrome. Everything here will be synthesized in a lab. This is because when you are dealing with stuff that the body produces, it's a LOT easier to synthesize it in the lab than to extract it from a natural source and purify it!

Hope that explains things, if not just ask :)

23113514? ago

Explains alot, thanks!

23113541? ago

No worries! I know a fair bit of chem and bio so I'm familiar with papers and experiments like these, I'm always happy to offer an explanation! I'm PinkyPunk if you want to ask me anything in the future :)

23113597? ago

Maybe i will.!

23113487? ago

Natural is ALWAYS better than synthetic, everybody knows that.

23113526? ago

It's the same thing, it's the same chemical. It's really important to understand this point - when you synthesize something in a lab, you are making the exact same thing as the body makes. If you weren't, it wouldn't work.

Adrenaline is used medically for loads of things, eg epi pens - imagine if we had to extract that from blood! Adrenaline was first synthesized in 1901, so it's not hard to make.

Think about something like insulin. We used to get that from pregnant horse urine, which was labor intensive, and not very nice for the horses (they basically tied pregnant horses to walls and made them drink a lot). We can now just make it in a lab. You can use willow bark, or you can use aspirin, which is handy if you don't live near a willow tree.

One of the main reasons synthetic is better for medical use - when you take a natural product like blood or urine from another animal or person, especially blood, you have to purify it enough not to trigger the recipient's immune system.