Liddle' with an apostrophe - What message is POTUS making? Is it a troll on the spelling and grammar police? (QRV)

submitted ago by 3447679?

In a previous tweet POTUS stated:

"Low ratings @CNN purposely took the hyphen out and said I spelled the word little wrong," Trump tweeted. "A small but never ending situation with CNN!"

In this below tweet President Trump demonstrates no issues with knowledge of how to use a hyphen (-) when he tweeted "so-called" along with Liddle' (with the apostrophe)

https://twitter.com/realDonaldTrump/status/1178074545443479553

What sort of game is this? Is there another message in there that only Schifty knows?

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20757124? ago

Any famous people who's last name is liddle? Apostrophe is possessive, maybe he's saying (person named liddle') Adam Schiff.

AS connected to someone named liddle'?

20757147? ago

There's also a genetic disease called liddles. It's heavily pedigreed meaning only few families have this disease. Any kidney issues or low salt diets in Adam Schiff a family or people within his orbit? What about him?

20757683? ago

[LIDDLE' SYNDROME]

Other Names:

Pseudoaldosteronism; Liddle's syndrome

Categories:

Blood Diseases; Congenital and Genetic Diseases; Kidney and Urinary Diseases

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Summary

Liddle syndrome is a rare, inherited condition that is primarily characterized by severe high blood pressure (hypertension) that often develops at an early age. Although the condition may not be associated with signs and symptoms initially, untreated hypertension can eventually lead to heart disease or stroke. Affected people may also have low levels of potassium in the blood (hypokalemia) and metabolic alkalosis. Liddle syndrome is caused by mutations in either the SCNN1B or SCNN1G genes and is inherited in an autosomal dominant manner. Treatment may include a low sodium diet and potassium-sparing diuretics to reduce blood pressure and normalize potassium levels. Conventional anti-hypertensive therapies are not effective.[1][2]

Last updated: 11/15/2016

Symptoms

Liddle syndrome is primarily characterized by severe, early-onset hypertension (high blood pressure). Although the condition may not be associated with any signs and symptoms initially, untreated hypertension can eventually lead to heart disease and stroke. Affected people may also have hypokalemia (low blood potassium) and metabolic alkalosis. Symptoms of hypokalemia can include weakness, fatigue, muscle pain (myalgia), constipation or heart palpitations. In most cases, the condition becomes apparent at a young age but some affected people are not diagnosed until well into adulthood.[2][1]

Last updated: 11/15/2016

This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.

Showing 14 of 14 |

Medical Terms Other Names

Learn More:

HPO ID

80%-99% of people have these symptoms

Arrhythmia

Abnormal heart rate

Heart rhythm disorders

Irregular heart beat

Irregular heartbeat

[ less ] 0011675

Constipation 0002019

Hypertension 0000822

Hypokalemia

Low blood potassium levels

0002900

30%-79% of people have these symptoms

Cerebral ischemia

Disruption of blood oxygen supply to brain

0002637

Fatigue

Tired

Tiredness

[ less ] 0012378

Muscle weakness

Muscular weakness

0001324

Nephropathy 0000112

Renal insufficiency

Renal failure

Renal failure in adulthood

[ less ] 0000083

Percent of people who have these symptoms is not available through HPO

Autosomal dominant inheritance 0000006

Decreased circulating aldosterone level

Low blood aldosterone level

0004319

Decreased circulating renin level 0003351

Hypokalemic alkalosis 0001949

Metabolic alkalosis 0200114

Showing 14 of 14 |

Do you have more information about symptoms of this disease? We want to hear from you.

Last updated: 9/1/2019

Do you have updated information on this disease? We want to hear from you.

Cause

Liddle syndrome is caused by changes (mutations) in the SCNN1B or SCNN1G gene. Each of theses genes provides instructions for making one piece of a protein complex called the epithelial sodium channel (ENaC). These channels are found on the surface of certain cells (epithelial cells) throughout the body, including the kidneys, lungs, and sweat glands. The ENaC channel transports sodium into cells.[3][4]

Mutations in the SCNN1B and SCNN1G genes affect an important region of the protein involved in signaling for its breakdown (degradation). As a result of the mutations, the protein is not tagged for degradation when it is no longer needed, and more ENaC channels remain at the cell's surface. The increase in channels at the cell surface abnormally increases the reabsorption of sodium, which leads to hypertension. Because removal of potassium from the blood is linked with reabsorption of sodium, excess sodium reabsorption leads to hypokalemia.[1]

Last updated: 11/15/2016

Inheritance

Liddle syndrome is inherited in an autosomal dominant manner.[1] This means that to be affected, a person only needs a change (mutation) in one copy of the responsible gene in each cell. In some cases, an affected person inherits the mutation from an affected parent. Other cases may result from new (de novo) mutations in the gene. These cases occur in people with no history of the disorder in their family. A person with Liddle syndrome has a 50% chance with each pregnancy of passing along the altered gene to his or her child.

Last updated: 11/15/2016

Diagnosis

A diagnosis of Liddle syndrome is often suspected based the presence of early-onset hypertension (high blood pressure), especially in people with a family history of the condition. Additional testing can then be ordered to confirm the diagnosis. This may include:[5][2]

20757689? ago

CONTINUED >

Blood tests which can detect low levels of potassium, renin and aldosterone.
Urine tests to identify low levels of sodium and aldosterone.
Genetic testing to look for a change (mutation) in the SCNN1B or SCNN1G gene.

Last updated: 11/16/2016

Testing Resources

The Genetic Testing Registry (GTR) provides information about the genetic tests for this condition. The intended audience for the GTR is health care providers and researchers. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.

Treatment

Treatment for Liddle syndrome consists of following a low sodium diet and taking potassium-sparing diuretics, which reduce blood pressure and correct hypokalemia and metabolic alkalosis. Conventional anti-hypertensive therapies are not effective for this condition.[5][2]

Last updated: 11/16/2015

Management Guidelines

Project OrphanAnesthesia is a project whose aim is to create peer-reviewed, readily accessible guidelines for patients with rare diseases and for the anesthesiologists caring for them. The project is a collaborative effort of the German Society of Anesthesiology and Intensive Care, Orphanet, the European Society of Pediatric Anesthesia, anesthetists and rare disease experts with the aim to contribute to patient safety.

Prognosis

With treatment, the long-term outlook (prognosis) for people with Liddle syndrome is good. However, untreated hypertension may lead to stroke, heart disease and/or kidney problems which can be fatal.[1][5]

Last updated: 11/16/2016

Find a Specialist

If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease. You may find these specialists through advocacy organizations, clinical trials, or articles published in medical journals. You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments.

If you can’t find a specialist in your local area, try contacting national or international specialists. They may be able to refer you to someone they know through conferences or research efforts. Some specialists may be willing to consult with you or your local doctors over the phone or by email if you can't travel to them for care.

You can find more tips in our guide, How to Find a Disease Specialist. We also encourage you to explore the rest of this page to find resources that can help you find specialists.

Healthcare Resources

To find a medical professional who specializes in genetics, you can ask your doctor for a referral or you can search for one yourself. Online directories are provided by the American College of Medical Genetics and the National Society of Genetic Counselors. If you need additional help, contact a GARD Information Specialist. You can also learn more about genetic consultations from Genetics Home Reference.

Related Diseases

Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.

Conditions with similar signs and symptoms from Orphanet

The clinical picture resembles that of primary hyperaldosteronism (see this term) but the hormonal profile resembles that of hyporeninism-hypoaldosteronism (see this term).

Visit the Orphanet disease page for more information.

Research

Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.

Clinical Research Resources

ClinicalTrials.gov lists trials that are related to Liddle syndrome. Click on the link to go to ClinicalTrials.gov to read descriptions of these studies.

Please note: Studies listed on the ClinicalTrials.gov website are listed for informational purposes only; being listed does not reflect an endorsement by GARD or the NIH. We strongly recommend that you talk with a trusted healthcare provider before choosing to participate in any clinical study.

Organizations

Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.

Organizations Supporting this Disease

American Heart Association
7272 Greenville Avenue
Dallas, TX 75231-4596
Toll-free: 800-242-8721
Telephone: 214-570-5978
E-mail: [https://www.heart.org/en/forms/general-questions-and-latest-research-information](https://www.heart.org/en/forms/general-questions-and-latest-research-information)
Website: [https://www.heart.org](https://www.heart.org)

END

After what he's done , I'll BET SCHITT has [LIDDLE' SYNDROME] alright , both genetically , and worsened by the situation he finds himself in . POTUS knows it , and is TROLLING THE LIVING DAYLIGHTS out of this PO_Schitt. TRUMP owns his dumb ass, and he is doing EXACTLY what Trump wants him to do, which is look like a fuckwit, and EXPOSE ALL THE DIRT. Schitt is a KEY figure to bring down.

LITERALLY = an AVALANCHE of D5 PROPORTIONS [CATEGORY FIVE] as POTUS said in his DORIAN (THE STORM) press briefing a few weeks ago at the start of it all.

See this DECODE from that time, and all connected decodes to POTUS and DORIAN. CONNECT THE DOTS >

https://voat.co/v/QRV/3413197

DORIAN specific >

https://voat.co/v/QRV/3409049

https://voat.co/v/QRV/3412790

Remember the story of DORIAN GRAY. SYMBOLIC. <

DORIAN = 61

HURRICANE DORIAN = 610

QANON = 61

D5

D + ORIAN (D + 5 letters), with ORIAN being an anagram of ORIAN

Break Schitt, and the rest start to FALL like [DOMINOES].

'o-o' <

20757826? ago

Oh my God. What if bidens bloody eye is a symptom of high blood pressure. Which is a symptom of liddles disease. With liddles being hereditary and dominate in expression, there's a 50% chance of inheritance with every child!

20757870? ago

(((THEY))) are all connected by BLOODLINES.

FOLLOW THE BLOODLINES. FOLLOW THE WIVES. FOLLOW THE CHILDREN.

See Fritz Springmeir.