I don't know enough organic chemistry to work out if there is a relevant link here perhaps one of you can tell me.

In this paper: Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2. - https://www.ncbi.nlm.nih.gov/pubmed/29526807

There is increasing evidence that oxidative stress is involved in the etiology and pathogenesis of neurodegenerative disorders. Overproduction of reactive oxygen species (ROS) is due in part to the reactivity of catecholamines, such as dopamine, adrenaline, and noradrenaline. These molecules are rapidly converted, chemically or enzymatically, into catechol-quinone and then into highly deleterious semiquinone radicals after 1-electron reduction in cells. Notably, the overexpression of dihydronicotinamide riboside:quinone oxidoreductase (QR2) in Chinese hamster ovary (CHO) cells increases the production of ROS, mainly superoxide radicals, when it is exposed to exogenous catechol-quinones (e.g. dopachrome, aminochrome, and adrenochrome).

Discovery of Novel Targets of Quinoline Drugs in the Human Purine Binding Proteome - https://www.researchgate.net/profile/Michael_Foley9/publication/11031678_Discovery_of_Novel_Targets_of_Quinoline_Drugs_in_the_Human_Purine_Binding_Proteome/links/56cd3ee108aeb52500c0a432.pdf

The quinolines have been used in the treatment of malaria,

arthritis, and lupus for many years, yet the precise mechanism

of their action remains unclear. In this study, we used a functional proteomics approach that exploited the structural similarities between the quinoline compounds and the purine ring of ATP to identify quinoline-binding proteins. Several quinoline drugs were screened by displacement affinity chromatography against the purine binding proteome captured with
-phosphate-linked ATP-Sepharose. Screening of the human red

blood cell purine binding proteome identified two human proteins, aldehyde dehydrogenase 1 (ALDH1) and quinone reductase 2 (QR2). ). In contrast, no proteins were detected upon

screening of the Plasmodium falciparum purine binding proteome with the quinolines. In a complementary approach, we passed cell lysates from mice, red blood cells, or P. falciparum over hydroxychloroquine- or primaquine-Sepharose. Consistent with the displacement affinity chromatography screen, ALDH and QR2 were the only proteins recovered from mice and human red blood cell lysate and no proteins were recovered from P. falciparum. Furthermore, the activity of QR2 was potently inhibited by several of the quinolines in vitro. Our results

show that ALDH1 and QR2 are selective targets of the quinolines and may provide new insights into the mechanism of action of these drugs.