I agree the effects are nothing like hard opiates, but strictly speaking, kratom does contain opiate agonists.
It pisses me off that the FDA feels the need to control that people put in their bodies. What really infuriates me is when the FDA restricts access to drugs that can actually help people break their dependance on much worse drugs.
Fact is, kratom as a powdered leaf has its own built-in anti-abuse system. The leaf is really hard on the digestive system, and you have to take grams of the powder to get an effect, even with no tolerance. So people that try and abuse the stuff generally just end up puking the stuff back up. The only people that continue to use those high doses are those that would have nausea anyway, from the withdrawals caused by other drugs they're trying to get off of.
According to wiki it's an NMDA antagonist and u-opioid agonist. Personally I wouldn't use it. All the active compounds have two or more methoxy groups, which fuck with microtubule polymerization.
Thanks for bringing some science into the discusion. Id still risk it if I had to get off of painkillers, but I agree that its generally not a good substance to consume.
You have my attention. Where can I learn why this is a health issue?
My searches return stuff a bit beyond my comprehension. I'm more of an armchair scientist than legit. So it doesn't have to be dumb, I'd like to know what you're talking about.
I frequent that forum. As he says, all microtubule dissolving molecules have methoxy groups and from my limited searching, methoxy groups on a benzene ring, such as in colchicine, make them particularly potent.
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SayTan ago
No it isn't. Nothing at all like morphine or opium. Are they gonna close the bar?
https://www.moonkratom.com
Its_Just_A_Ride ago
I agree the effects are nothing like hard opiates, but strictly speaking, kratom does contain opiate agonists.
It pisses me off that the FDA feels the need to control that people put in their bodies. What really infuriates me is when the FDA restricts access to drugs that can actually help people break their dependance on much worse drugs.
Fact is, kratom as a powdered leaf has its own built-in anti-abuse system. The leaf is really hard on the digestive system, and you have to take grams of the powder to get an effect, even with no tolerance. So people that try and abuse the stuff generally just end up puking the stuff back up. The only people that continue to use those high doses are those that would have nausea anyway, from the withdrawals caused by other drugs they're trying to get off of.
cosmic_climb ago
According to wiki it's an NMDA antagonist and u-opioid agonist. Personally I wouldn't use it. All the active compounds have two or more methoxy groups, which fuck with microtubule polymerization.
Its_Just_A_Ride ago
Thanks for bringing some science into the discusion. Id still risk it if I had to get off of painkillers, but I agree that its generally not a good substance to consume.
Waiyu_Dudat ago
You have my attention. Where can I learn why this is a health issue?
My searches return stuff a bit beyond my comprehension. I'm more of an armchair scientist than legit. So it doesn't have to be dumb, I'd like to know what you're talking about.
cosmic_climb ago
This is a good primer.
https://raypeatforum.com/community/threads/intelligent-people-more-likely-to-suffer-from-mental-illness.20445/page-2#post-284121
I frequent that forum. As he says, all microtubule dissolving molecules have methoxy groups and from my limited searching, methoxy groups on a benzene ring, such as in colchicine, make them particularly potent.
SayTan ago
See also: Ibogaine and LSD
RickFlairWOOOOOO ago
With Guns drawn! THey some ass holes!