Interestingly Paul Krugman and Larry Sommers have said similar things about TPP - it won't have a HUGE impact on 1) The global economy and 2) Americans losing manufacturing jobs, which is a large amount of opposition voiced in the MSM. Read here: http://krugman.blogs.nytimes.com/2015/03/11/tpp-at-the-nabe/?_r=0. But this is not really the biggest concern for most Americans. It is the intellectual property laws and the handing of power to corporations in a way that makes domestic law impotent that is so frightening. When corporations can sue governments so freely, this essentially provides another route for companies to siphon money from the tax payers, since this is where government money comes from. Also, lack of access to medicine is pretty concerning.

Here is a quote from the top comment that makes the point pretty well: "Strange. PK devotes an entire post to TPP and doesn't mention what is the most concerning aspect of it to me, and many others. It represents a bald faced attack on the ability of democratically elected governments to regulate the corporate sector. It replaces regulation and the court system with a star chamber of corporate lawyer/lobbyists who take turns arguing before the chamber and sitting in judgment. It then awards reparations on the basis of "lost future profits" with little to no appeal. We the people have no advocate in these proceedings."