You are viewing a single comment's thread.

view the rest of the comments →

MercurysBall2 ago

ADRENALINE AND ADRENOCHROME By DAVID EZRA GREEN1 AND DEREK RICHTER, From the Biochemical Laboratory, Cambridge (1937) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266980/pdf/biochemj01050-0115.pdf

GREEN & BROSTEAUX [1936] and Green [1936, 2] showed that the lactic and malic dehydrogenases of animal tissues could react with oxygen only in presence of coenzyme I, a carrier and a ketone fixative. The dehydrogenase catalysed the transfer of hydrogen from the substrate to the coenzyme; in turn the reduced coenzyme reduced the carrier, and finally reduced carrier reacted with molecular oxygen. The function of the ketone fixative consisted in binding the keto-acid formed by the oxidation of either lactic or malic acid. The product of oxidation

in both cases completely arrested the catalytic oxidation unless removed by the ketone reagent.

Adrenaline, flavin and flavoprotein were the only substances occurring in animal tissues which were found capable of acting as carriers in the lactic and malic systems. The mechanism of the flavin and flavoprotein effects was perfectly clear. These substances were alternately reduced by the coenzyme and oxidized by molecular oxygen. This simple interpretation however failed to account for the adrenaline effect. The experiments of Green & Brosteaux [1936] and Green [1936, 2] showed clearly that the action of adrenaline as an oxidation carrier involved a complicated mechanism.

MercurysBall2 ago

Whitchurch Psychiatric Hospital, Cardiff https://en.wikipedia.org/wiki/Whitchurch_Hospital

https://twitter.com/cardiffian_news/status/708300833260183552

Powerful play pays tribute to history of Whitchurch psychiatric hospital #Whitchurch #play

https://imgur.com/a/HrcXh5B