Scientific studies which include adrenochrome (thinkdrafts)

submitted ago by MercurysBall2

https://worldwidescience.org/topicpages/a/adrenochrome.html

Differential action on cancer and normal tissue by adrenochrome monoaminoguanidine methanesulfonate and cytochrome C combined with radiotherapy - International Nuclear Information System (INIS) by Nakatsugawa, S.; Sugahara, T. (1994)

Pulse-radiolytic investigations of catechols and catecholamines - International Nuclear Information System (INIS) by Bors, W.; Saran, M.; Michel, C.; Lengfelder, E.; Fuchs, C.; Spoettl, R. (1975)

[Involvement of carbonate/bicarbonate ions in the superoxide-generating reaction of adrenaline autoxidation]. - Science.gov (United States) by Sirota, T V (2015)

Spectrophotometric investigation on the kinetics of oxidation of adrenaline by dioxygen of μ-dioxytetrakis(histidinato)-dicobalt(II) complex - Science.gov (United States) by Rafiquee, M. Z. A.; Siddiqui, Masoom R.; Ali, Mohd. Sajid; Al-Lohedan, Hamad A.

[Standardization and regulation of the rate of the superoxide-generating adrenaline autoxidation reaction used for evaluation of pro/antioxidant properties of various materials]. - Science.gov (United States) by Sirota T V (2016)

A novel method of adrenaline concentration detection using fiber optical biosensor based on the catalysis of iron(II) phthalocyanine by Zhou, Xuan; Huang, Jun; Li, Mingtian; Wang, Bin (2008)

Clinical experiences with a chemical radioprotector in tumor radiotherapy: WR-2721 - International Nuclear Information System (INIS) by Tanaka, Y. (1984)

Bladder hemorrhage after radiotherapy for carcinoma of the cervix uteri - International Nuclear Information System (INIS) by Matsuyama, Toshitake; Tsukamoto, Naoki; Sugimori, Hajime; Yoshino, Teruo; Kashiwamura, Masamichi. (1979)

Synthesis of silver nanoparticle. A new analytical approach for the quantitative assessment of adrenaline - International Nuclear Information System (INIS) by Siddiqui, Masoom R.; Rafiquee, M.Z.A.; Wabaidur, Saikh M.; Alothman, Zeid A.; Ali, Mohammad S.; Allohedan, Hamad A. (2015)

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MercurysBall2 ago

ADRENALINE AND ADRENOCHROME By DAVID EZRA GREEN1 AND DEREK RICHTER, From the Biochemical Laboratory, Cambridge (1937) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266980/pdf/biochemj01050-0115.pdf

GREEN & BROSTEAUX [1936] and Green [1936, 2] showed that the lactic and malic dehydrogenases of animal tissues could react with oxygen only in presence of coenzyme I, a carrier and a ketone fixative. The dehydrogenase catalysed the transfer of hydrogen from the substrate to the coenzyme; in turn the reduced coenzyme reduced the carrier, and finally reduced carrier reacted with molecular oxygen. The function of the ketone fixative consisted in binding the keto-acid formed by the oxidation of either lactic or malic acid. The product of oxidation

in both cases completely arrested the catalytic oxidation unless removed by the ketone reagent.

Adrenaline, flavin and flavoprotein were the only substances occurring in animal tissues which were found capable of acting as carriers in the lactic and malic systems. The mechanism of the flavin and flavoprotein effects was perfectly clear. These substances were alternately reduced by the coenzyme and oxidized by molecular oxygen. This simple interpretation however failed to account for the adrenaline effect. The experiments of Green & Brosteaux [1936] and Green [1936, 2] showed clearly that the action of adrenaline as an oxidation carrier involved a complicated mechanism.

MercurysBall2 ago

Quinone https://en.wikipedia.org/wiki/Quinone

The quinones are a class of organic compounds that are formally "derived from aromatic compounds [such as benzene or naphthalene] by conversion of an even number of –CH= groups into –C(=O)– groups with any necessary rearrangement of double bonds", resulting in "a fully conjugated cyclic dione structure".[1] The class includes some heterocyclic compounds.

Occurrence and uses

  • Production of hydrogen peroxide

  • Biochemistry

Derivatives of quinones are common in biologically active molecules. Some serve as electron acceptors in electron transport chains such as those in photosynthesis (plastoquinone, phylloquinone), and aerobic respiration (ubiquinone). Phylloquinone is also known as Vitamin K1 as it is used by animals to carboxylate certain proteins, which are involved in blood coagulation, bone formation, and other processes. Conversely, the toxicity of paracetamol is due to its metabolism to a quinone imine, which then reacts with liver proteins to cause liver failure.

..The auto-oxidation of the neurotransmitter dopamine and its precursor L-Dopa generates the comparatively stable dopamine quinone which inhibits the functioning of dopamine transporter (DAT) and the TH enzyme leading to low mitochondrial ATP production.

  • Medicinal

Natural or synthetic quinones show a biological or pharmacological activity, and some of them show anti-tumoral activity. They embody some claims in herbal medicine.

  • Dyes

Many natural and artificial coloring substances (dyes and pigments) are quinone derivatives. They are second only to azo dyes in importance as dyestuffs, with particular emphasis on blue colors.

  • Battery charge carrier

9,10-Anthraquinone-2,7-disulphonic acid (AQDS) a quinone similar to one found naturally in rhubarb has been used as a charge carrier in metal-free flow batteries.